conclusions hcv coinfection, older age and ast were associated with lf in patients with hiv infection. objectives the aim of this cross-sectional study was to identify factors associated with liver fibrosis (lf) in patients with hiv monoinfection and hiv-hcv coinfection. patients and methods we analyzed lf by transient elastometry ([te], fibroscan) in three groups of patients (hiv, hiv-hcv and ...

AIM To investigate the relationships among diverse metalloproteases (MMPs) and their tissue inhibitors (TIMPs) and non-alcoholic liver fibrosis in human immunodeficiency virus (HIV)-infected patients. METHODS Single nucleotide polymorphisms (SNPs) in MMPs, TNF-α and CCR5 genes, and serum levels of MMPs and TIMPs were determined in HIV-infected individuals with/out hepatitis C virus (HCV) coin...

Fibrosis progression after acute hepatitis C virus (HCV) infection in human immunodeficiency virus (HIV)-infected patients with follow-up >9 months became similar to reported rates from studies in chronic HIV/HCV coinfection, as measured with transient elastometry. The duration of follow-up and serum alanine transaminase correlated with liver stiffness, and short follow-up resulted in high fibr...

INTRODUCTION Hepatic fibrosis is secondary to many etiologies (alcohol, viruses...) and the quantification of this fibrosis is a key point for the clinician. Hepatic puncture biopsy is the invasive gold standard for the assessment of degree of fibrosis. Many techniques, more or less reliable and a bit or not invasive, have been developed to evaluate it. Among those techniques, utrasonic transie...

BACKGROUND Advanced liver fibrosis frequently develops in patients with chronic hepatitis C coinfected with HIV. Non-invasive techniques for staging liver fibrosis, such as transient elastometry, may allow both periodic monitoring and examination of large patient populations. METHODS A programme of liver fibrosis assessment using transient elastometry has been ongoing at our institution since...

Methods A prospective study in which HIV-HCV coinfected patients were randomized to receive either pegylated IFNa-2a 180 μg/week plus ribavirin (RBV) at two different doses: i) 1000-1200 mg/day (arm A) or ii) 2000 mg/ day plus erythropoietin (EPO) from baseline to week 4 (arm B), was conducted. Patients not achieving RVR prolonged therapy to 48 weeks for G2-3 and to 72 for G1-4. Liver fibrosis ...

BACKGROUND Due to the high efficacy of combination antiretroviral therapy (cART), the number of patients living with HIV is increasing. Chronic HCV infection has become a leading cause of non-AIDS related morbidity and mortality in patients with HIV infection. OBJECTIVES The aim of this cross-sectional study was to identify factors associated with liver fibrosis (LF) in patients with HIV mono...

Systems of planar electrodes arranged on dielectric or piezoelectric layers are applied in numerous sensors and transducers. In this paper electrostatics of such electrode systems is presented and exploited in the analysis of distributed piezoelectric transducer dedicated to surface elastometry of biological tissues characterized by large Poisson modulus. The fundamental Matlab R © code for ana...